Inspired by the pioneering work of Walter Schubert, TNL was founded in April 2006 as a Spin-Off of the university of Magdeburg, Germany. The company´s overall goal is to provide the Imaging Cycler® robot technology for the scientific community through its recently founded Human Toponome Project (see HUTO project) and to transfer knowledge in toponome-technology and -biology to the benefit of customers in the life sciences, thereby accelerating developments in toponomics. To achieve this goal TNL provides a team which is highly experienced in technical and biological toponomics to leverage toponome research in the scientific community. TNL ensures that customers will profit by the fast development of toponome tools, assays and data bases generated by interacting partners. TNL believes that biology drives toponomics. Because of trademarking reasons the former company name Toponome-International Ltd. was changed to ToposNomos Ltd. in June 2008.


Network of institutions experienced in / associated with toponomics:

ToposNomos Network

  1. Molecular Pattern Recognition Research (MPRR) Group, Otto-von-Guericke University, Magdeburg, Germany
  2. Bielefeld University, Dept. of Neuroinformatics, Bielefeld, Germany
  3. University of the Saarland, Dept. of Neurodegeneration and Neurobiology, Homburg/Saar, Germany
  4. Max Planck Institute for Mathematics in the Sciences, Leipzig, Germany
  5. Centre for Membrane Proteomics, University of Frankfurt, Germany
  6. University of Warwick, Mathematics Institute, Coventry, United Kingdom
  7. CAS MPG Partner Institute for Computational Biology (PICB) Shanghai, China
  8. ToposNomos Ltd., Munich, Germany
  9. University College London & King's College London, London, United Kingdom
  10. Novamen / ACIES Consulting Group, Lyon, France
  11. University of Zurich, Zurich, Switzerland
  12. Uppsala University, Uppsala, Sweden
  13. Innoprot, Derio-Bizkaia, Spain

References (selected)

Schubert W, Gieseler A, Krusche A, Serocka P, Hillert R. "Next-generation biomarkers based on 100-parameter functional super-resolution microscopy TIS."
N Biotechnol. 2012 Jun 15;29(5):599-610.

Oeltze S, Freiler W, Hillert R, Doleisch H, Preim B, Schubert W. "Interactive, graph-based visual analysis of high-dimensional, multi-parameter fluorescence microscopy data in toponomics." IEEE Trans Vis Comput Graph. 2011 Dec; 17(12):1882-91.

Bhattacharya S, Mathew G, Ruban E, Epstein DB, Krusche A, Hillert R, Schubert W, Khan M. "Toponome imaging system: in situ protein network mapping in normal and cancerous colon from the same patient reveals more than five-thousand cancer specific protein clusters and their subcellular annotation by using a three symbol code." J Proteome Res. 2010 Dec 3; 9(12):6112-25.

Schubert W. "On the origin of cell functions encoded in the toponome." J Biotech- nol. 2010 Sep 15; 149(4):252-9.

Schubert W, Gieseler A, Krusche A, Hillert R. "Toponome mapping in prostate cancer: detection of 2000 cell surface protein clusters in a single tissue section and cell type specific annotation by using a three symbol code." J Proteome Res. 2009 Jun; 8(6):2696-707.

Schubert W, Friedenberger M, Bode M, Krusche A, Hillert R. "Functional architecture of the cell nucleus: towards comprehensive toponome reference maps of apoptosis." Biochim Biophys Acta. 2008 Nov; 1783(11):2080-8.

Bode M, Irmler M, Friedenberger M, May C, Jung K, Stephan C, Meyer HE, Lach C, Hillert R, Krusche A, Beckers J, Marcus K, Schubert W. "Interlocking transcriptomics, proteomics and toponomics technologies for brain tissue analysis in murine hippocampus." Proteomics. 2008 Mar; 8(6):1170-8.

Schubert W. "Breaking the biological code." Cytometry A. 2007 Oct; 71(10):771-2.

Schubert W. "A three-symbol code for organized proteomes based on cyclical imaging of protein locations." Cytometry A. 2007 Jun; 71(6):352-60.

Friedenberger M, Bode M, Krusche A, Schubert W. "Fluorescence detection of protein clusters in individual cells and tissue sections by using toponome imaging system: sample preparation and measuring procedures." Nat Protoc. 2007; 2(9):2285-94.

Bode M, Krusche A. "Toponome Imaging System (TIS): Imaging the proteome with functional resolution." Nat Meth. 2007; 4:iii-iv.

Schubert W, Bonnekoh B, Pommer AJ, Philipsen L, Böckelmann R, Malykh Y, Gollnick H, Friedenberger M, Bode M, Dress AWM. "Analyzing proteome topology and function by automated multi-dimensional fluorescence microscopy." Nat Biotechnol. 2006 Oct; 24(10):1270-8.

Dress A, Lokot T, Pustyl´nikov LD, Schubert W. "Poisson numbers and poisson distributions in subset surprisology." Ann. Comb. 2004; 8:473-485.

Schubert W. "Multiple antigen-mapping microscopy of human tissue." In Excerpta Medica (Burger G, Oberholzer M, Voojs GP, editors). 1990 pp 97-98, Elsevier.

Schubert W. "Cytomics in characterizing toponomes: towards the biological code of the cell." Cytometry A. 2006 Apr; 69(4):209-11.

Schubert W. "Exploring molecular networks directly in the cell." Cytometry A. 2006 Mar; 69(3):109-12.

Schubert W. "Topological proteomics, toponomics, MELK-technology." Adv Biochem Eng Biotechnol. 2003; 83:189-209.

Events (selected)

HUPO world congress in Seoul, South Korea, 6-10 Oct. 2007. Walter Schubert has given an invited lecture "The human TOPONOME project: Decipher the organized core proteome until 2020".

Teaching toponomics. Walter Schubert has given a teaching course for students in toponomics at university of Helsinki, Finland in November 2006.

Press releases (German)



Archive click here



ToposNomos International Ltd.
Wakefield, Munich, Magdeburg